Search on: LACTASE-PHLORIZIN HYDROLASE 
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Descriptor English:   Lactase-Phlorizin Hydrolase 
Descriptor Spanish:   Lactasa-Florizina Hidrolasa 
Descriptor Portuguese:   Lactase-Florizina Hidrolase 
Synonyms English:   Glycosylceramidase
Phloretin-Glucosidase
Phlorizin Hydrolase  
Tree Number:   D08.811.277.450.410.100.500.500
D08.811.277.450.420.475
D08.811.641.761
Definition English:   The multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE. 
See Related English:   Lactose Intolerance
 
History Note English:   2014(1992) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   30404 
Unique Identifier:   D010694 

Occurrence in VHL:
 

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